Abbreviation for Vascular Endothelial Growth Factor C. An under expression of this gene has been found and/or is believed to be responsible for Milroy's Disease (Milroy's Syndrome), Hereditary Lymphedema I.
An over expression of VEGF-C is indicative of lymphatic (cancer) metastasis.
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.
* Pathophysiology of Lymphedema
* Milroy's Syndrome
Genetics, Research, Lymphangiogenesis, Angiogenesis
VEGF and its relationship to inflammatory mediators.
A novel VEGFR3 mutation causes Milroy disease.
Roles of VEGFR-2 and VEGFR-3 signaling in adult lymphangiogenesis
VEGF and PlGF promote adult vasculogenesis
PIGF antagonizes VEGF induced angiogenesis - tumor growth
Interaction of VEGF-C and VEGF-D with neuropilin receptors
Lymphatic hyperplasia, VEGF-C upregulation, MMP-9.
Milroy's Disease (lymphedema) and the VEGFR3 (FLT3)
The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy
Lymphangiogenesis Breast Cancer the VEGF-C
Lymphangiogenesis and Gastric Cancer
Lymphangiogenesis in Head and Neck Cancer
Lymphangiogenesis and Kaposi's Sarcoma VEGF-C
Lymphangiogenesis and Melanoma
Lymphangiogenesis in Wound Healing
A model for gene therapy of human hereditary lymphedema
VEGFR-3 Ligands and Lymphangiogenesis (1)
VEGFR-3 Ligands and Lymphangiogenesis (2)
VEGFR-3 Ligands and Lymphangiogenesis (3)
Vascular Endothelial Growth Factor; VEGF
VEGF-D is the strongest angiogenic and lymphangiogenic effector
Inhibition of Lymphatic Regeneration by VEGFR3
VEGFR3 and Metastasis in Prostate Cancer
Radiogeneic Lymphangiogenesis in the Skin
Dose-dependent response of FGF-2 for lymphangiogenesis
Lymphangiogenesis Signalling Pathways in Human Disease
Lymphangiogenesis, inflammation and metastasis
Lymphatic endothelial cells, lymphangiogenesis, cell matrix
Influence of IFN- alpha and IFN- gamma on Lymphangiogenesis.
Expression of VEGF-C angiogenesis, lymphangiogenesis Cancer
VEGF-C gene therapy, Lymphangiogensis and Lymphedema
Molecular lymphangiogenesis: new players.