/glo·mer·u·lo·scle·ro·sis/ (glo-mer?u-lo-skle-ro´sis) fibrosis and scarring resulting in senescence of the renal glomeruli.
Intercapillary g. Rounded hyaline or laminated nodules in the periphery of the renal glomeruli with capillary basement membrane thickening and increased mesangial matrix. Also called intercapillary glomerulosclerosis
(1) A syndrome of focal sclerosing lesions of the renal glomeruli with proteinuria, hematuria, hypertension, and nephrosis, with variable progression to end-stage renal disease. (2) Focal segmental glomerulosclerosis is scar tissue that forms in areas of the kidney that filter certain things out of the body. These areas are called glomeruli. The help the body get rid of harmful or unnecessary substances. Each kidney has thousands of glomeruli.
A degenerative complication of diabetes mellitus in humans, with albuminuria, edema, hypertension, renal insufficiency and retinopathy. A small proportion of diabetic dogs have roughly similar lesions of diffuse or nodular hyaline deposits in glomeruli. The characteristic nodules are referred to as Kimmelstiel-Wilson nodules. Called also intercapillary glomerulosclerosis.