Lymphangiogenesis
Breast Cancer the VEGF-C
--------------------------------------------------
Angiogenesis (blood vessel growth), lymphangiogenesis (lymph system growth) are all intrinsically connected with lymphedema and share many of the same genes. We have several pages on both processes.
May 23, 2008
--------------------------------------------------
Induction of tumor lymphangiogenesis by VEGF-C
promotes
breast cancer metastasis
Mihaela Skobe1, Thomas Hawighorst1, David G. Jackson2, Remko Prevo2,
Lauren
Janes1, Paula Velasco1, Lucia Riccardi1, Kari Alitalo3, Kevin Claffey4
&
Michael Detmar1
Metastasis of breast cancer occurs primarily through the lymphatic
system, and
the extent of lymph node involvement is a key prognostic factor for the
disease.
Whereas the significance of angiogenesis for tumor progression has been
well
documented, the ability of tumor cells to induce the growth of
lymphatic vessels
(lymphangiogenesis) and the presence of intratumoral lymphatic vessels
have been
controversial. Using a novel marker for lymphatic endothelium, LYVE-1,
we
demonstrate here the occurrence of intratumoral lymphangiogenesis
within human
breast cancers after orthotopic transplantation onto nude mice.
Vascular
endothelial growth factor (VEGF)-C overexpression in breast cancer
cells
potently increased intratumoral lymphangiogenesis, resulting in
significantly
enhanced metastasis to regional lymph nodes and to lungs. The degree of
tumor
lymphangiogenesis was highly correlated with the extent of lymph node
and lung
metastases. These results establish the occurrence and biological
significance
of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C
as a
molecular link between tumor lymphangiogenesis and metastasis.
1. Cutaneous Biology Research Center, Department of Dermatology,
Massachusetts
General Hospital and Harvard Medical School, Charlestown,
Massachusetts, USA
2. Institute of Molecular Medicine, John Radcliffe Hospital,
Headington, Oxford,
UK
3. Molecular/Cancer Biology Laboratory and Ludwig Institute for Cancer
Research,
Haartman Institute, University of Helsinki, Helsinki, Finland
4. University of Connecticut Health Center, Farmington, Connecticut, USA
Correspondence should be addressed to M Detmar. e-mail: michael.detmar@cbrc2.mgh.harvard.edu
http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/v7/n2/abs/nm0201_192.html&dynoptions=doi1102862595
===========================
Abstracts and Studies
=====
http://www.nature.com/modpathol/journal/v18/n1/full/3800253a.html
===========================
Lymphedema People Angiogenesis Related Pages:
Angiogenesis
http://www.lymphedemapeople.com/thesite/angiogenesis.htm
Angiogenesis and Cancer
http://www.lymphedemapeople.com/thesite/angiogenesis_and_cancer.htm
Angiogenesis and Cancer
Control
http://www.lymphedemapeople.com/thesite/angiogenesis_and_cancer_control.htm
Angiogenesis Inhibitors
and Cancer
http://www.lymphedemapeople.com/thesite/angiogenesis_inhibitors_and_cancer.htm
===========================
Lymphedema People Lymphangiogenesis Related Pages:
The Formation of
Lymphatic Vessels and Its Importance in the Setting of Malignancy
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_formation_of_lymphatic_vessels_and_malignancy.htm
Lymphangiogenesis
Lymphedema and Cancer
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_lymphedema_and_cancer.htm
Lymphangiogenesis and
Gastric Cancer
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_and_gastric_cancer.htm
Lymphangiogenesis in Head
and Neck Cancer
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_in_head_and_neck_cancer.htm
Lymphangiogenesis and
Kaposi's Sarcoma VEGF-C
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_and_kaposis_sarcoma_vegfc.htm
Lymphangiogenesis in
Wound Healing
http://www.lymphedemapeople.com/thesite/lymphangiogenesis_in_wound_healing.htm
A model for gene therapy
of human hereditary
lymphedema
http://www.lymphedemapeople.com/thesite/a_model_for_gene_therapy_of_human_lymphedema.htm
VEGFR-3 Ligands and
Lymphangiogenesis (1)
http://www.lymphedemapeople.com/thesite/vegfr3_ligands_lymphangiogenesis_1.htm
VEGFR-3 Ligands and
Lymphangiogenesis (2)
http://www.lymphedemapeople.com/thesite/vegfr3_ligands_lymphangiogenesis_2.htm
VEGFR-3 Ligands and
Lymphangiogenesis (3)
http://www.lymphedemapeople.com/thesite/vegfr3_ligands_lymphangiogenesis_3.htm
Vascular Endothelial
Growth Factor; VEGF
http://www.lymphedemapeople/thesite/vascular_endothelial_growth_factor_VEGF.htm
VEGF-D is the strongest
angiogenic and
lymphangiogenic effector
http://www.lymphedemapeople.com/thesite/VEGFD_Angiogenic_Lymphangiogenic_Effector.htm
Inhibition of Lymphatic
Regeneration by VEGFR3
http://www.lymphedemapeople.com/thesite/Inhibition_of_Lymphatic_Regeneration_by_VEGFR3.htm
VEGFR3 and Metastasis in
Prostate Cancer
http://www.lymphedemapeople.com/thesite/VEGFR3_and_Metastasis_in_Prostate_Cancer.htm
===========================
Lymphedema People Genetics, Research, Lymphangiogenesis, Angiogenesis Forum
http://www.lymphedemapeople.com/phpBB2/viewforum.php?f=16
===========================
Join us as we work for lymphedema patients everywehere:
Advocates for Lymphedema
Dedicated to be an advocacy group for lymphedema patients. Working towards education, legal reform, changing insurance practices, promoting research, reaching for a cure.
http://health.groups.yahoo.com/group/AdvocatesforLymphedema/
Subscribe: | AdvocatesforLymphedema-subscribe@yahoogroups.com |
Pat O'Connor
Lymphedema People / Advocates for Lymphedema
===========================
For information about Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema\
For Information about Lymphedema Complications
http://www.lymphedemapeople.com/wiki/doku.php?id=complications_of_lymphedema
For Lymphedema Personal Stories
http://www.lymphedemapeople.com/phpBB2/viewforum.php?f=3
For information about How to Treat a Lymphedema Wound
http://www.lymphedemapeople.com/wiki/doku.php?id=how_to_treat_a_lymphedema_wound
For information about Lymphedema Treatment
http://www.lymphedemapeople.com/wiki/doku.php?id=treatment
For information about Exercises for Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=exercises_for_lymphedema
For information on Infections Associated with Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=infections_associated_with_lymphedema
For information on Lymphedema in Children
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_in_children
Lymphedema Glossary
http://www.lymphedemapeople.com/wiki/doku.php?id=glossary:listing
===========================
Lymphedema People - Support Groups
-----------------------------------------------
Children
with Lymphedema
The time has come for families, parents, caregivers to have a support
group of
their own. Support group for parents, families and caregivers of
chilren with
lymphedema. Sharing information on coping, diagnosis, treatment and
prognosis.
Sponsored by Lymphedema People.
http://health.groups.yahoo.com/group/childrenwithlymphedema/
Subscribe: childrenwithlymphedema-subscribe@yahoogroups.com
......................
Lipedema
Lipodema Lipoedema
No matter how you spell it, this is another very little understood and
totally
frustrating conditions out there. This will be a support group for
those
suffering with lipedema/lipodema. A place for information, sharing
experiences,
exploring treatment options and coping.
Come join, be a part of the family!
http://health.groups.yahoo.com/group/lipedema_lipodema_lipoedema/?yguid=209645515
Subscribe: lipedema_lipodema_lipoedema-subscribe@yahoogroups.com
......................
MEN WITH LYMPHEDEMA
If you are a
man with lymphedema; a man with a loved one with lymphedema who you are
trying
to help and understand come join us and discover what it is to be the
master
instead of the sufferer of lymphedema.
http://health.groups.yahoo.com/group/menwithlymphedema/
Subscribe: menwithlymphedema-subscribe@yahoogroups.com
......................
All
About Lymphangiectasia
Support group for parents, patients, children who suffer from all forms
of
lymphangiectasia. This condition is caused by dilation of the
lymphatics. It can
affect the intestinal tract, lungs and other critical body areas.
http://health.groups.yahoo.com/group/allaboutlymphangiectasia/
Subscribe: allaboutlymphangiectasia-subscribe@yahoogroups.com
......................
Lymphatic
Disorders Support Group @ Yahoo Groups
While we have a number
of support groups for lymphedema... there is nothing out there for
other
lymphatic disorders. Because we have one of the most comprehensive
information
sites on all lymphatic disorders, I thought perhaps, it is time that
one be
offered.
DISCRIPTION
Information and support for rare and unusual disorders affecting the
lymph
system. Includes lymphangiomas, lymphatic malformations,
telangiectasia,
hennekam's syndrome, distichiasis, Figueroa
syndrome, ptosis syndrome, plus many more. Extensive database of
information
available through sister site Lymphedema People.
http://health.groups.yahoo.com/group/lymphaticdisorders/
Subscribe: lymphaticdisorders-subscribe@yahoogroups.com
===========================
Lymphedema People New Wiki Pages
Have
you seen our new “Wiki”
pages yet? Listed
below are just a
sample of the more than 140 pages now listed in our Wiki section. We
are also
working on hundred more. Come
and
take a stroll!
Lymphedema
Glossary
http://www.lymphedemapeople.com/wiki/doku.php?id=glossary:listing
Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema
Arm
Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=arm_lymphedema
Leg
Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=leg_lymphedema
Acute
Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=acute_lymphedema
The
Lymphedema Diet
http://www.lymphedemapeople.com/wiki/doku.php?id=the_lymphedema_diet
Exercises
for Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=exercises_for_lymphedema
Diuretics
are not for Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=diuretics_are_not_for_lymphedema
Lymphedema
People Online Support
Groups
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_people_online_support_groups
Lipedema
http://www.lymphedemapeople.com/wiki/doku.php?id=lipedema
Treatment
http://www.lymphedemapeople.com/wiki/doku.php?id=treatment
Lymphedema
and Pain Management
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_and_pain_management
Manual
Lymphatic Drainage (MLD) and Complex Decongestive Therapy (CDT)
Infections
Associated with Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=infections_associated_with_lymphedema
How
to Treat a Lymphedema Wound
http://www.lymphedemapeople.com/wiki/doku.php?id=how_to_treat_a_lymphedema_wound
Fungal
Infections Associated with
Lymphedema
http://www.lymphedemapeople.com/wiki/doku.php?id=fungal_infections_associated_with_lymphedema
Lymphedema
in Children
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_in_children
Lymphoscintigraphy
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphoscintigraphy
Magnetic
Resonance Imaging
http://www.lymphedemapeople.com/wiki/doku.php?id=magnetic_resonance_imaging
Extraperitoneal
para-aortic lymph node dissection (EPLND)
Axillary
node biopsy
http://www.lymphedemapeople.com/wiki/doku.php?id=axillary_node_biopsy
Sentinel
Node Biopsy
http://www.lymphedemapeople.com/wiki/doku.php?id=sentinel_node_biopsy
Small
Needle Biopsy - Fine Needle Aspiration
http://www.lymphedemapeople.com/wiki/doku.php?id=small_needle_biopsy
Magnetic
Resonance Imaging
http://www.lymphedemapeople.com/wiki/doku.php?id=magnetic_resonance_imaging
Lymphedema
Gene FOXC2
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_gene_foxc2
Lymphedema Gene VEGFC
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_gene_vegfc
Lymphedema Gene SOX18
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_gene_sox18
Lymphedema
and Pregnancy
http://www.lymphedemapeople.com/wiki/doku.php?id=lymphedema_and_pregnancy
Home page: Lymphedema People
http://www.lymphedemapeople.com
Page Updated: Dec. 24, 2011