Cutaneous lymphomas assoc with lymphoproliferative disorders

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Cutaneous lymphomas assoc with lymphoproliferative disorders

Postby patoco » Sun May 13, 2007 5:26 am

Sometimes, the new research that comes out isn't so exciting or
encouraging, but at least it is important to have. When I first was
diagnosed with lymphoma in the left leg in 1995, the doctors were so
bewildered as they just had never heard of lymphoma in a lymphedema

The only cancer they hear associated with lymphedema was this nasty
stuff called Stewart Treeves Syndrome (lymphangiosarcoma). When I
was diagnosed with the second type of lymphoma in 2000, it really
made them go crazy.

Since that time, there have been four distinct cancers that have been
linked to long term and/or untreated lymphedema.
They are lymphangiosarcoma, Kaposi's Sarcoma, T-cell cutaneous
lymphoma and B-cell lymphoma.

Now a study has finally come out that backs me up in what I was
trying to get across to these medicine men years ago.

*****High frequency of primary cutaneous lymphomas associated with lymphoproliferative disorders of different lineage.

Ann Hematol. 2007 Mar 6;

Hallermann C, Kaune Kjell M, Tiemann M, Kunze E, Griesinger F,
Mitteldorf C, Bertsch HP, Neumann C.
Department of Dermatology, University of Goettingen, Goettingen,

In patients suffering from primary cutaneous lymphomas, secondary
malignancies of various origin may develop. However, the frequency of
a second neoplasm deriving from another lymphoid lineage is still
unclear and may be underestimated. We screened all our patients with
primary cutaneous lymphomas from a 4-year recruitment period for a
coexisting secondary lymphoproliferative disorder. The cohort
comprised of a total of 82 patients with primary cutaneous lymphomas,
62 with primary cutaneous T-cell lymphoma (CTCL), 18 with primary
cutaneous B-cell lymphomas, and two with CD4+/CD56+ hematodermic
neoplasm/blastic lymphomas. Seven patients (8.5%) were identified
with a coexisting lymphoma of a different lymphoid lineage. Four
patients with Sézary syndrome (SS) suffered from systemic B-cell
lymphoma. Two of these developed SS after chemotherapy of their B-
cell lymphoma. The other three patients with various types of skin
lymphomas (SS, Mycosis fungoides [MF], primary cutaneous marginal
zone lymphoma) developed Hodgkin's disease (hairy cell leukemia). Our
data indicate that patients with primary cutaneous lymphomas have an
elevated risk for the development of a secondary lymphoproliferative
disorder even without previous chemotherapy. Possible explanations
for this association include a genetic predisposition, alterations in
early progenitor cells, underlying viral infections, and/or
stimulation of a B-cell clone by the malignant helper T cells of the
primary CTCL and vice versa.

Keywords Hairy cell leukemia, Cutaneous T-cell lymphoma, Sézary


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