Selenium, Lymphedema and Cancer - Update

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Selenium, Lymphedema and Cancer - Update

Postby patoco » Thu Aug 10, 2006 8:25 am

Selenium, Lymphedema and Cancer

Lymphedema People


A number of years ago, selenium was used to treat lymphedema. While
many promises were made, it actually failed to prove it's effectiveness
in independant clinical studies.

Here is a just published new study that seems to verify earlier


Selenium for alleviating the side effects of chemotherapy, radiotherapy
and surgery in cancer patients.

Dennert G, Horneber M.

BACKGROUND: Selenium supplements are frequently used by cancer patients. Selenium is an essential trace element and is involved in
antioxidant protection and redox-regulation in humans. Several adverse
effects of radiotherapy and chemotherapy in cancer patients as well as
cellular processes that maintain chronic lymphoedema have been linked
to oxidative cell damage in the human body. Selenium has recently been
investigated as a remedy against chemotherapy and
radiotherapy-associated side effects as well as its effects on

OBJECTIVES: This review assessed the effects of supplementary selenium on adverse effects of conventional radiotherapy, chemotherapy, or surgery, in oncologic patients and on quality of life or performance
status during and after oncologic treatment.

SEARCH STRATEGY: We searched the Cochrane Pain, Palliative & Supportive Care Trials Register, the Cochrane Database of Systematic Reviews (The Cochrane Library , Issue 2, 2004), Medline (1966 - Sep 2004), Embase (1980 - 2004 week 12), SIGLE (October 2004), Cancerlit (October 2004), Clinical Contents in Medicine CCMed (October 2004), the German Register of Cancer Studies (October 2004), the NCI Clinical Trials Register (October 2004), the International Standard Randomised Controlled Trial Number Register ISRCTN (October 2004) and the Meta-Register of Controlled Trials mRCT (October 2004), reference lists and the archive of our working group. We contacted manufacturers of selenium
supplements and investigators.

SELECTION CRITERIA: Randomised-controlled trials of selenium
mono-supplements in cancer patients undergoing tumour specific therapy
such as chemotherapy, radiotherapy or surgery.

DATA COLLECTION AND ANALYSIS: Two review authors independently checked trials for eligibility, extracted data and assessed trial quality. We sought additional information from investigators when required.

MAIN RESULTS: Two trials have been included, a randomised controlled trial with 60 participants at the beginning of the study investigating secondary lymphoedema and an ongoing trial with preliminary results of 63 participants investigating radiotherapy induced diarrhoea as a secondary outcome. Both trials had drawbacks with regard to study quality and reporting.The trial on secondary lymphoedema reported a decreased number of recurrent erysipela infections in the selenium supplementation group compared to placebo. However, results must be interpreted with caution and cannot be generalised to other
populations. The ongoing trial on radiotherapy associated diarrhoea
preliminarily reported a lower incidence of diarrhoea in patients
receiving selenium supplementation concomitant to pelvic radiation,
however, no data were presented. Publication of final results must be
awaited to discuss these findings in detail.No randomised controlled
trials were found studying the effect of selenium supplementation on
other therapy-associated toxicities or quality of life or performance
status in cancer patients.

AUTHORS' CONCLUSIONS: There is insufficient evidence at present that selenium supplementation alleviates the side effects of tumour specific chemotherapy or radiotherapy treatments. Or, that it improves the after effects of surgery, or improves quality of life in cancer patients or reduces secondary lymphoedema. To date research findings do not provide a basis for any recommendation in favour or against selenium
supplementation in cancer patients. Potential hazards of supplementing
a trace mineral should be kept in mind.

PMID: 16856073 [PubMed - in process] ... etrieve&...
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