Possible Future Use of Administration of Injectable Meds

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Possible Future Use of Administration of Injectable Meds

Postby mother1991 » Sun Jul 18, 2010 5:33 pm

I came acros this today and was thinking that if this is effective then aminstration of injectable medications, immunization, and Vitamins for tose with lymphedema may be helpful especially if have more than one limb effected with lymphedema and also helpful with children with disorder too. I am thinking do not if medically it cause complications with lymphedema but the microneedle patch that dissolves could be helpful for those in more remote areas, and for those where leaving home is a hard could help to keep healthier and it can be attached by a person with very very little medical training or none at all especially for those that administer own injections at home or have family member that does. This also I think would help lessen the anxiety and have better compliance then if not used. I know it still a bit off and mice are the only test subject in this manner but an interesting way to look at technology that may be able to use for other uses.

Here is article and link:
Vaccine-delivery patch with dissolving microneedles eliminates 'sharps,' boosts protection

A new vaccine-delivery patch based on hundreds of microscopic needles that dissolve into the skin could allow persons without medical training to painlessly administer vaccines - while providing improved immunization against diseases such as influenza.

Patches containing micron-scale needles that carry vaccine with them as they dissolve into the skin could simplify immunization programs by eliminating the use of hypodermic needles - and their "sharps" disposal and re-use concerns. Applied easily to the skin, the microneedle patches could allow self-administration of vaccine during pandemics and simplify large-scale immunization programs in developing nations.

Details of the dissolving microneedle patches and immunization benefits observed in experimental mice were reported July 18th in the advance online publication of the journal Nature Medicine. Conducted by researchers from Emory University and the Georgia Institute of Technology, the study is believed to be the first to evaluate the immunization benefits of dissolving microneedles. The research was supported by the National Institutes of Health (NIH).

"In this study, we have shown that a dissolving microneedle patch can vaccinate against influenza at least as well, and probably better than, a traditional hypodermic needle," said Mark Prausnitz, a professor in the Georgia Tech School of Chemical and Biomolecular Engineering.

Just 650 microns in length and assembled into an array of 100 needles for the mouse study, the dissolving microneedles penetrate the outer layers of skin. Beyond their other advantages, the dissolving microneedles appear to provide improved immunity to influenza when compared to vaccination with hypodermic needles.

This is the first image in a sequence showing how the microneedles dissolve in the skin. This image shows the microneedles before application to the skin. Credit: Credit: Sean Sullivan, Georgia Tech

"The skin is a particularly attractive site for immunization because it contains an abundance of the types of cells that are important in generating immune responses to vaccines," said Richard Compans, professor of microbiology and immunology at Emory University School of Medicine.

In the study, one group of mice received the influenza vaccine using traditional hypodermic needles injecting into muscle; another group received the vaccine through dissolving microneedles applied to the skin, while a control group had microneedle patches containing no vaccine applied to their skin. When infected with influenza virus 30 days later, both groups that had received the vaccine remained healthy while mice in the control group contracted the disease and died.

Three months after vaccination, the researchers also exposed a different group of immunized mice to flu virus and found that animals vaccinated with microneedles appeared to have a better "recall" response to the virus and thus were able to clear the virus from their lungs more effectively than those that received vaccine with hypodermic needles.

"Another advantage of these microneedles is that the vaccine is present as a dry formulation, which will enhance its stability during distribution and storage," said Ioanna Skountzou, an Emory University assistant professor.

Pressed into the skin, the microneedles quickly dissolve in bodily fluids, leaving only the water-soluble backing. The backing can be discarded because it no longer contains any sharps.

"We envision people getting the patch in the mail or at a pharmacy and then self administering it at home," said Sean Sullivan, the study's lead author from Georgia Tech. "Because the microneedles on the patch dissolve away into the skin, there would be no dangerous sharp needles left over."

The microneedle arrays were made from a polymer material, poly-vinyl pyrrolidone, that has been shown to be safe for use in the body. Freeze-dried vaccine was mixed with the vinyl-pyrrolidone monomer before being placed into microneedle molds and polymerized at room temperature using ultraviolet light.

This image shows a portion of a dissolving microneedle patch compared to a US nickel coin. Credit: Credit: Sean Sullivan, Georgia Tech

In many parts of the world, poor medical infrastructure leads to the re-use of hypodermic needles, contributing to the spread of diseases such as HIV and hepatitis B. Dissolving microneedle patches would eliminate re-use while allowing vaccination to be done by personnel with minimal training.

Though the study examined only the administration of flu vaccine with the dissolving microneedles, the technique should be useful for other immunizations. If mass-produced, the microneedle patches are expected to cost about the same as conventional needle-and-syringe techniques, and may lower the overall cost of immunization programs by reducing personnel costs and waste disposal requirements, Prausnitz said.

Before dissolving microneedles can be made widely available, however, clinical studies will have to be done to assure safety and effectiveness. Other vaccine formulation techniques may also be studied, and researchers will want to better understand why vaccine delivery with dissolving microneedles has been shown to provide better protection.

Beyond those already mentioned, the study involved Jeong-Woo Lee, Vladimir Zarnitsyn, Seong-O Choi and Niren Murthy from Georgia Tech, and Dimitrios Koutsonanos and Maria del Pilar Martin from Emory University.

"The dissolving microneedle patch could open up many new doors for immunization programs by eliminating the need for trained personnel to carry out the vaccination," Prausnitz said. "This approach could make a significant impact because it could enable self-administration as well as simplify vaccination programs in schools and assisted living facilities."


Provided by Georgia Institute of Technology
http://www.physorg.com/news198572549.html
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Re: Possible Future Use of Administration of Injectable Meds

Postby patoco » Mon Jul 19, 2010 9:20 am

Hey Mother :)

This is quite interesting. Thanks for posting it. This could also be a big help for those with arm lymphedema that should not have needles put into their arms.

There are already many meds that are used in patches, so let's hope they can perfect this to where it is widely available for all whole spectrum of medicines (even antitiobtics).

Pat
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Re: Possible Future Use of Administration of Injectable Meds

Postby Robert Hayes » Mon Jul 19, 2010 10:28 am

Where do I sign up for this? ...and I'm passing this on to Viro Pharma for the Cinryze prophylactic use for we Angio-edema bound...!!!?
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