Wuchereria bancrofti vespid, Immune response, Serum immune complexes diagnosis, Diethylcarbamazine (DEC), Wolbachia in filarial parasites, Interdigital skin lesions, Urban Filariasis, Doxycycline, mass drug administration program, Filarial Lymphedema Care, Detection of filarial parasites, Albendazole, research abstracts

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Postby patoco » Fri Apr 27, 2007 9:19 pm


Rev Prat. 2007 Jan

[Article in French]
Carme B.
Service de parasitologie et mycologie, equipe UPRES EA 3595, faculte de medecine Antilles-Guyane et centre hospitalier de Cayenne, BP 6006, 97306 Cayenne, Guyane francaise.

Filariasis are vector-transmitted parasitoses, exclusively tropical, except for dirofilariosis. Their impact differs according to the type of filaria and the induced immune response. The diagnosis is made based on the presence of dermatological or lymphatic manifestations, acute or chronic, associated with usually extended stays in an endemic country. It can also be established following a laboratory examination revealing hypereosinophilia or correspond to the incidental finding of microfilariae (blood or skin). The visualization of the embryonic and/or adult parasite confirms the infection. For pathogenic filariasis with microfilaremiae, paradoxically, clinically positive subjects are often amicrofilaremic. In this case, the presence of antibodies and/or specific serum antigens confirms the diagnosis. On the contrary, asymptomatic microfilariaecarriers are common but there is no guarantee that they will remain asymptomatic. The etiological treatment of choice is based on a combination of ivermectin and albendazole. However, diethylcarbamazine, which was formerly used, is still indicated. Dracunculiasis has been almost eradicated and the elimination of lymphatic filariasis and onchocerciasis as public health problems can be contemplated in the medium term.

PMID: 17432520 [PubMed - in process] ... med_docsum


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