Filarial and Wolbachia Genomics
Scott AL, Ghedin E, Nutman TB, McReynolds LA, Poole CB, Slatko BE, Foster JM.Source
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe, Baltimore, MA 21205, USA Department of Computational & Systems Biology, Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 New England Biolabs, 240 County Rd, Ipswich, MA 01938, USA.Abstract
Filarial nematode parasites, the causative agents of a spectrum of acute and chronic diseases including lymphatic filariasis and river blindness, threaten the wellbeing and livelihood of hundreds of millions of people in the developing regions of the world.
The 2007 publication on a draft assembly of the 95 Mb genome of the human filarial parasite Brugia malayi - representing the first helminth parasite genome to be sequenced - has been followed in rapid succession by projects that have resulted in the genome sequencing of six additional filarial species, seven non-filarial nematode parasites of animals and nearly thirty plant parasitic and free-living species. Parallel to the genomic sequencing, transcriptomic and proteomic projects have facilitated genome annotation, expanded our understanding of stage-associated gene expression and provided a first look at the role of epigenetic regulation of filarial genomes through microRNAs.
The expansion in filarial genomics will also provide a significant enrichment in our knowledge of the diversity and variability in the genomes of the endosymbiotic bacterium Wolbachia leading to a better understanding of the genetic principles that govern filarial-Wolbachia mutualism. The goal here is to provide an overview of the trends and advances in filarial and Wolbachia genomics.
Copyright © 2011 Blackwell Publishing Ltd.