Yellow nail syndrome: not a genetic disorder? Eleven cases

Lymphangiogenic Gene Therapy, yellow nail syndrome, lymphatic vascular development, Intratumoral lymphatics, peritumoral lymphatics, stem cell research, Angiopoietins, VEGF, PIGF, FOXC1, FOXC2, Lymphatic Insufficiency. SOX18, lymphatic hyperplasia, Molecular lymphangiogenesis, PROX1, FLT3, Telan­giectasia, Lymphatic endothelial cells, adult vasculogenesis, LYVE1

Moderators: Birdwatcher, jenjay, Cassie, patoco, Senior Moderators

Yellow nail syndrome: not a genetic disorder? Eleven cases

Postby patoco » Fri Apr 27, 2007 8:30 pm

Yellow nail syndrome: not a genetic disorder? Eleven new cases and a review of the literature.

Br J Dermatol. 2007 Apr 25

Hoque SR, Mansour S, Mortimer PS.
Department of Dermatology, St Helier Hospital, Carshalton, Surrey, UK.

Background Yellow nail syndrome (YNS) is characterized by the triad of characteristic nail changes, chronic respiratory disorders and primary lymphoedema. Over 100 cases have been published, most of which have been sporadic. Despite this, YNS is classified as a dominantly inherited lymphoedema with variable expression. There have been only a few published reports where a positive family history (FH) has been documented in cases of YNS. Objectives To conduct a retrospective survey investigating the genetic basis of YNS. Methods The notes of 11 patients diagnosed with YNS were examined for documentation of a positive FH, and in addition a postal questionnaire was sent to these patients. Results Only one of the 11 patients had a relevant FH. In addition, four patients had complete recovery of their nail changes. Conclusions This is the first retrospective study of YNS to document clear remission of nail changes. The lack of a positive FH in the majority of patients in our study, the late onset of the disease and recovery of nail changes in our patients suggest that YNS may not be primarily a genetic disease as it is currently classified.

PMID: 17459037 [PubMed - as supplied by publisher] ... med_docsum


Pat O'Connor
Lymphedema People
User avatar
Site Admin
Posts: 2175
Joined: Thu Jun 08, 2006 9:07 pm

Return to Genetics, Research, Lymphangiogenesis, Angiogenesis

Who is online

Users browsing this forum: No registered users and 8 guests