Lymphatic endothelial cells, lymphangiogenesis, cell matrix

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Lymphatic endothelial cells, lymphangiogenesis, cell matrix

Postby patoco » Fri Sep 22, 2006 10:25 am

Lymphat Res Biol. 2006 Summer;4(2):83-100.

Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.

Ji RC.

Department of Anatomy, Biology and Medicine, Oita University Faculty of
Medicine, Oita, Japan.

Exciting studies involving the molecular regulation of
lymphangiogenesis in lymphatic-associated disorders (e.g., wound
healing, lymphedema and tumor metastasis) have focused renewed
attention on the intrinsic relationship between lymphatic endothelial
cells (LECs) and extracellular matrix (ECM) microenvironment. ECM
molecules and remodeling events play a key role in regulating
lymphangiogenesis, and the "functionality"-relating molecules,
especially hyaluronan, integrins, reelin, IL-7, and matrix
metalloproteinases, provide the most fundamental and critical
prerequisite for LEC growth, migration, tube formation, and survival,
although lymphangiogenesis is directly or/and indirectly controlled by
VEGF-C/-D/VEGFR- 3- Prox-1-, Syk/SLP76-, podoplanin/Ang-2/Nrp-2-,
FOXC2-, and other signaling pathways in embryonic and pathological

New knowledge regarding the differentiation of initial
lymphatics should enable improvements in understanding of a variety of
cytokines, chemokines, and other factors.

The lymphatic colocalization with histochemical staining by using the
novel molecular markers (e.g., LYVE-1), along with subsequent injection
technique with ferritin or some tracer, will reveal functional and
structural features of newly formed and preexisting lymphatics.

Growing recognition of the multiple functions of ECM and LEC molecules for important physiological and pathological events may be helpful in
identifying the crucial changes in tissues subjected to lymph
circulation and ultimately in the search for rational therapeutic
approaches to prevent lymphatic-associated disorders.

PMID: 16808670 [PubMed - in process] ... med_docsum


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