Angiogenic role of LYVE-1-positive macrophages in adipose ti

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Angiogenic role of LYVE-1-positive macrophages in adipose ti

Postby patoco » Fri May 25, 2007 2:12 am

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

Circ Res. 2007 Mar 2

*** LYVE-1 is a central compenent of lymphatic development. It is being studied for its involvment in lymphedema as is the entire subject of how adipogenesis works in conjunction to lymphangiogensis ***

Cho CH, Koh YJ, Han J, Sung HK, Jong Lee H, Morisada T, Schwendener
RA, Brekken RA, Kang G, Oike Y, Choi TS, Suda T, Yoo OJ, Koh GY.
National Research Laboratory of Vascular Biology and Department of
Biological Sciences, Korea Advanced Institute of Science and
Technology, Daejeon, Korea.

Here we report the discovery of a characteristic dense vascular
network (DVN) in the tip portion of epididymal adipose tissue in adult
mice. The DVN is formed by angiogenesis rather than by vasculogenesis,
and has functional blood circulation. This DVN and its subsequent
branching may provide a new functional route for adipogenesis. The
recruitment, infiltration, and accumulation of bone marrow-derived
LYVE-1(+) macrophages in the tip region are crucial for the formation
of the DVN. Matrix metalloproteinases (MMPs) and the VEGF-VEGFR2
system are responsible not only for the formation of the DVN, but also
for the recruitment and infiltration of LYVE-1(+) macrophages into the
epididymal adipose tissue tip region. SDF-1, but not the MCP-1-CCR2
system, is a critical factor in recruitment and ongoing retention of
macrophages in this area.

We also demonstrate that the tip region of epididymal adipose tissue is highly hypoxic, and thus provides a microenvironment conducive to the high expression and enhanced activities of VEGF, VEGFR2, MMPs, and SDF-1 in autocrine and paracrine manners, to create an ideal niche for the recruitment, retention, and angiogenic action of macrophages. These findings shed light on the complex interplay between macrophage infiltration, angiogenesis, and adipogenesis in the tip region of adult epididymal adipose tissue, and provide novel insight into the regulation of alternative outgrowth of adipose tissue.

Key Words: adipogenesis · angiogenesis · lymphatic vessel hyaluronan receptor 1 · macrophages · matrix metalloproteinases · monocyte chemoattractant protein-1 · vascular endothelial growth factor

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