SPECT-CT: a valuable method to document the regeneration of

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SPECT-CT: a valuable method to document the regeneration of

Postby patoco » Sat May 12, 2007 7:55 am

SPECT-CT: a valuable method to document the regeneration of lymphatics and autotransplanted lymph node fragments.

Eur J Nucl Med Mol Imaging. 2007 May 11

Blum KS, Radtke C, Knapp WH, Pabst R, Gratz KF.
Department of Functional and Applied Anatomy, Medical School of Hannover, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany, blum.katrin@mh-hannover.de.

PURPOSE: The transplantation of lymph node fragments and stimulation of lymph vessel regeneration seems to be a promising model to prevent lymphoedema in patients after mammary tumour excision combined with axillary lymph node dissection and irradiation. This study evaluated the advantages of SPECT-CT in studying the regeneration of lymph vessels and lymphoid tissue after autologous lymph node transplantation.

METHODS: Five minipigs underwent autologous lymph node transplantation in the left groin. The lymph node was excised, cut into six pieces and embedded into two newly created subcutaneous pouches on this side. The superficial lymph node of the right groin was removed as a control. Five months after surgery the lymph flow of both legs was investigated using conventional lymphoscintigraphy and SPECT-CT with 10 MBq(99m)Tc-nanocolloid in combination with Berlin Blue injected subcutaneously into the draining area.

RESULTS: The integration of the transplanted lymph node fragments was shown. The SPECT-CT results correlated with the in situ findings observed at dissection. Afferent and efferent lymph flow could be followed up to the lumbar trunks. The use of SPECT-CT allowed exact localisation of the lymph node fragments in three-dimensional space and the regeneration of the lymph node fragments was documented histologically.

CONCLUSION: SPECT-CT is a good method to evaluate lymphatic flow and document lymph node regeneration. The data suggest that autologous lymph node transplantation is a promising model for prevention of lymphoedema.

PMID: 17492446 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum

***** Editor's Notes *****

I posted this article as information on the SPECT-CT and its usefulness in studying the lymp system. I still STRONGLY disagree with the concept of lymph node transplantaion.

If lymphedema is caused by the removal of lymph nodes, then when you take nodes from one area to move to another, I feel you simply change the site that is "at risk" for eventual development of lymphedema.

There simply has not been enough time to measure the real safety of this procedure.

Pat O'Connor
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